💊 FDA-Approved GLP-1 Therapy: Our FREE semaglutide reconstitution calculator 2026 provides pharmaceutical-grade calculations for Ozempic® and Wegovy® protocols. Calculate exact semaglutide to ml conversion, peptide ratios, and injection units for 2026 weight loss and diabetes treatment in the USA. Essential for compounding pharmacies, clinics, and responsible patient use.
| Week | Dose | Units* |
|---|---|---|
| 1-4 | 0.25 mg | - |
| 5-8 | 0.5 mg | - |
| 9-12 | 1.0 mg | - |
| 13+ | 1.7-2.4 mg | - |
Get pharmaceutical-grade calculations for safe and effective treatment
Semaglutide reconstitution requires precise pharmaceutical calculations to ensure accurate dosing for weight loss and diabetes treatment. Our semaglutide calculator 2026 follows FDA guidelines and USA compounding standards to provide clinic-grade accuracy for both Ozempic® (semaglutide) and Wegovy® (semaglutide) protocols.
Standard 5mg/2ml Reconstitution: 5mg semaglutide ÷ 2ml bacteriostatic water = 2.5mg/ml concentration
0.25mg Dose Calculation: 0.25mg ÷ 2.5mg/ml = 0.1ml volume needed
100 unit/ml Syringe: 0.1ml × 100 units/ml = 10 units on syringe
Total Doses from 5mg Vial: 5mg ÷ 0.25mg = 20 doses at starting dose
Monthly Cost Calculation: (Vial Cost ÷ Total Doses) × 4 doses/month
All calculations follow 2026 FDA and USP compounding standards for USA practice
| Week | Dose | Purpose | Expected Weight Loss | USA Insurance Coverage |
|---|---|---|---|---|
| 1-4 | 0.25 mg weekly | Initiation | 2-4% body weight | Prior auth usually required |
| 5-8 | 0.5 mg weekly | Titration | 4-6% body weight | Continued therapy |
| 9-12 | 1.0 mg weekly | Effective dose | 6-8% body weight | BMI ≥30 or ≥27 with comorbidity |
| 13-16 | 1.7 mg weekly | Approaching maintenance | 8-10% body weight | Documented response needed |
| 17+ | 2.4 mg weekly | Maintenance | 10-15% body weight | Long-term with periodic review |
USA Insurance Note: Most plans require documented weight loss of ≥5% at 3 months to continue coverage.
| Week | Dose | A1C Reduction | Cardiovascular Benefit | USA Medicare Coverage |
|---|---|---|---|---|
| 1-4 | 0.25 mg weekly | Minimal (initiation only) | Not established | Part D covered |
| 5-8 | 0.5 mg weekly | 0.7-1.0% reduction | Emerging benefit | Standard formulary |
| 9+ | 1.0 mg weekly | 1.2-1.5% reduction | Proven CV risk reduction | Preferred with prior auth |
| Special | 2.0 mg weekly | Additional 0.3-0.4% | Enhanced CV benefit | Limited to specific plans |
Medicare Note: Ozempic® typically covered for type 2 diabetes, Wegovy® coverage varies by Medicare Advantage plan.
Using our semaglutide reconstitution calculator with standard 5mg/2ml reconstitution: 0.25mg dose = 10 units on a 100 unit/ml syringe (0.1ml). For 2mg/1ml reconstitution: 0.25mg = 12.5 units. Always verify with your specific reconstitution using our calculator above.
For a 10mg semaglutide vial: 1) Use 3-4ml bacteriostatic water (not sterile water), 2) Gently inject water down the vial side (don't shoot directly at powder), 3) Roll gently between hands for 1-2 minutes until clear, 4) Never shake as it can denature the peptide. Our calculator provides exact dosing for 10mg vials.
According to USA compounding standards (USP Chapter 797), reconstituted semaglutide lasts 28 days maximum when refrigerated at 36-46°F (2-8°C). After 28 days, discard even if solution appears clear. This is why our calculator shows total doses per vial - plan your reconstitution to use within 28 days.
Ozempic®/Wegovy®: FDA-approved, pre-filled pens, specific doses (0.25, 0.5, 1.0, 2.0mg), insurance coverage common. Compounded semaglutide: Prepared by compounding pharmacies, customizable doses, often cheaper cash price, requires careful reconstitution calculation. Both contain semaglutide but differ in formulation and regulation.
MEDICAL EMERGENCY: Call 911 or go to ER immediately. This is a 10x overdose which can cause severe hypoglycemia, pancreatitis, or other serious complications. Monitor blood sugar every 15 minutes if conscious. Never attempt to "correct" with food or glucose alone - this requires emergency medical care.
Black Box Warning (FDA): Semaglutide has risk of thyroid C-cell tumors. Contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.
Common Side Effects: Nausea (44%), diarrhea (30%), vomiting (24%), constipation (24%), abdominal pain (21%). Usually diminish over 4-8 weeks.
Serious Risks: Pancreatitis, gallbladder disease, hypoglycemia (when with insulin/sulfonylureas), diabetic retinopathy complications, acute kidney injury.
USA Reporting: Report adverse events to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch.
Thousands of USA patients and professionals trust our calculations
NOT MEDICAL ADVICE: This semaglutide reconstitution calculator 2026 is for educational purposes only. Semaglutide is a prescription medication requiring medical supervision. Always consult with a licensed healthcare provider before starting or changing any medication regimen.
FDA Regulations: In the USA, semaglutide is available as FDA-approved Ozempic® (for diabetes) and Wegovy® (for weight loss). Compounded semaglutide may be available but varies by state pharmacy regulations.
Legal Compliance: This calculator does not encourage or facilitate misuse of prescription medications. Users are responsible for complying with all applicable federal and state laws regarding prescription medications.
Accuracy Note: While we strive for pharmaceutical accuracy, always double-check calculations with a healthcare professional. Report medication errors to FDA MedWatch.
Last Update: January 1, 2026 | Next Review: July 1, 2026